Lupus & antiphospholipid syndrome
Cardiac magnetic resonance feature tracking evaluates left atrial strain in patients with systemic lupus erythematosus and mitral regurgitation
Authors' conclusion
MRI-FT based LA parameters may be considered a helpful tool to evaluate LA function in SLE patients, and LA strain may indicate severity of the cardiac dysfunction in SLE patients.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients (35.0 ± 12.3 years, 49 females) and age- and gender-matched healthy controls64 SLE, 50 controls
- Participants
- 32 / 32 / 50
- Exposure
- SLE with mitral regurgitation vs SLE without mitral regurgitation vs healthy controls
- Mitral regurgitationn = 32
- Non-mitral regurgitationn = 32
- Healthy controlsn = 50reference
- Outcome
- Left atrial (LA) volume and strain parameters by magnetic resonance imaging feature tracking (MRI-FT)
Methodological detailsage- and gender-matched healthy controls, cardiac MRI feature tracking
- Age- and gender-matched healthy controls
- Cardiac MRI feature tracking
Main finding
As reported in the abstract
LAVmin
Mitral regurgitation
29.15
± 7.5
Non-mitral regurgitation
26.22
± 8.23
Healthy controls
21.68
± 7.67
Mitral regurgitation vs Healthy controls: P = 0.003 · Non-mitral regurgitation vs Healthy controls: .026
Observational data: associations, not effects.
Further findings
| Outcome | Mitral regurgitation | Non-mitral regurgitation | Healthy controls |
|---|---|---|---|
| LAVimin | 17.44 | 14.9 | 12.62 |
- LAVmin · Mitral regurgitation vs Healthy controls
- P = 0.003
- LAVmin · Non-mitral regurgitation vs Healthy controls
- .026
LAVimin
- Higher LAVimin in both SLE subgroups than healthy controls
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cardiac magnetic resonance feature tracking evaluates left atrial strain in patients with systemic lupus erythematosus and mitral regurgitation. Lupus. Published 20 May 2025. doi:10.
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