Lupus & antiphospholipid syndrome
Comparative Performance of LFA ‐ REAL , Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) , and BILAG for Detecting Clinically Meaningful Changes in Lupus Activity
Authors' conclusion
LFA-REAL showed comparable performance relative to SLEDAI and BILAG in detecting clinician-rated change. There was a statistically significant advantage over SLEDAI for detection of improvement.
Study context
- Population
- Adults with SLE, evaluated at baseline and follow-up visit, four centers145 (89%) completed follow-up
- Participants
- 163 adults
- Exposure
- Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) vs BILAG vs SLEDAI for detecting clinician-rated change
- Outcome
- Detection of CGIC-defined improvement and worsening (ROC AUC)
- Follow-up
- Visit
Methodological detailsmulticentre (four centers), ROC curve analysis, Youden Index cut-offs
- Multicentre (four centers)
- ROC curve analysis
- Youden Index cut-offs
Main finding
As reported in the abstract
CGIC-defined improvement, AUC
| Group | AUC |
|---|---|
| LFA-REAL | 0.85 (95% CI 0.77-0.92) |
| BILAG | 0.75 (95% CI 0.66-0.85) |
| SLEDAI | 0.74 (95% CI 0.64-0.84) |
AUC
LFA-REAL0.85 (95% CI 0.77-0.92)
BILAG0.75 (95% CI 0.66-0.85)
SLEDAI0.74 (95% CI 0.64-0.84)
- Clinician Global Impression of Change (CGIC): improved
- 23%
- CGIC: worsened
- 16%
- CGIC: stable
- 61%
Observational data: associations, not effects.
Further findings
Events
| Outcome | LFA-REAL | BILAG | SLEDAI |
|---|---|---|---|
| Patients with CGIC-defined worsening requiring treatment escalation (n = 8, 35%) identified by each instrument (LFA-REAL: difference of ≥10 mm) · follow-up visit | 8 | 4 | 2 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative Performance of LFA ‐ REAL , SLEDAI , and BILAG for Detecting Clinically Meaningful Changes in Lupus Activity. Arthritis Care Res (Hoboken). Published 10 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →