Lupus & antiphospholipid syndrome
Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity
Authors' conclusion
These results demonstrate a distinct clinical and serological SLE profile associated with components of the lectin pathway.
Study context
- Population
- Swedish patients with SLE and population-based matched controls
- Participants
- 522 vs 322
- Exposure
- Highest vs lower quartiles of serum MAP-1 and MASP-2 concentrations in patients with SLE
- SLEn = 522
- Controlsn = 322reference
- Outcome
- Associations of highest-quartile serum MAP-1 with SLE manifestations and autoantibodies
Methodological detailscase-control, population-based matched controls, logistic regression, genetic association analysis
- Case-control
- Population-based matched controls
- Logistic regression
- Genetic association analysis
Main finding
As reported in the abstract
- Discoid rash, MAP-1 highest quartile: OR
- 2.8 (95% CI 1.4 to 5.7)
- Haematological manifestations, MAP-1 highest quartile: OR
- 2.1 (95% CI 1.1 to 3.7)
- Autoantibodies against Sm, RNP, SSA and SSB, MAP-1 highest quartile: ORs 2.4 (95% CI 1.3 to 4.6) to 3.6
- 2.4 to 3.6 (95% CI 1.7 to 7.7)
- Anti-β2GP1 and aCL IgG and IgA aPL, highest quartiles of MAP-1 and MASP-2 (lower rates): ORs 0.29 (95% CI 0.12 to 0.68) to 0.56
- 0.29 to 0.56 (95% CI 0.31 to 1.0)
- Serum MAP-1 correlation with type I interferon activity, Spearman's rho (p<0.0001); interferon activity mediated MAP-1 associations with haematological manifestations and Sm/RNP autoantibodies
- 0.34
Observational data: associations, not effects.
Further findings
Protein quantitative trait loci for MAP-1 and MASP-2
- Significant pQTLs identified; no consistent associations with SLE or specific SLE manifestations
Original publication
Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity. Lupus Sci Med. Published 9 April 2026. doi:10.
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