Lupus & antiphospholipid syndrome
Adoption of multimodal echocardiography in evaluating left ventricular systolic synchrony in patients with systemic lupus erythematosus
Authors' conclusion
multimodal 2D echocardiography combined with 3D echocardiography parameters offers high Sen in predicting LVS function in patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy individuals undergoing 2D, 3D echocardiography and 3D-STI
- Participants
- 88 vs 50
- Comparison
- SLE vs healthy controls
- Disease group (DG)n = 88
- Control group (CG)n = 50reference
- Outcome
- LV systolic function assessed by multimodal ultrasound imaging (3D-STI parameters)
Methodological detailscase-control
- Case-control
Performance
As reported in the abstract
Diagnostic performance of 3D-STI systolic parameters
Overall left ventricular (LV) longitudinal strain: sensitivity
85.23%
Overall LV longitudinal strain: specificity
68%
Overall LV circumferential strain: sensitivity
90.91%
Overall LV circumferential strain: specificity
78%
Further findings
| Outcome | P value |
|---|---|
| 3D-STI systolic strains (longitudinal, circumferential, radial, area)Greatly inferior values in DG | P < 0.05 |
| Conventional echo: LV end-diastolic volume, stroke volume, cardiac output, LV end-diastolic and end-systolic mass, LV shortening fractionSubstantial differences | P < 0.05 |
| LV synchrony: segmental strain/rotation peaks, time differences, Tmsv-16Significant increase in DG · outperforming other indicators | P < 0.05 |
| Biomarkers: BNP, CK-MB, anti-α-actin, hs-CRPSignificantly higher in DG | P < 0.05 |
- LV synchrony: segmental strain/rotation peaks, time differences, Tmsv-16 — Tmsv-16 intraclass correlation coefficient (ICC)
- 0.90
- LV synchrony: segmental strain/rotation peaks, time differences, Tmsv-16 — Tmsv-16 coefficient of variation (CV)
- 4.5%
Original publication
Adoption of multimodal echocardiography in evaluating left ventricular systolic synchrony in patients with systemic lupus erythematosus. Lupus. Published 9 April 2026. doi:10.
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