Lupus & antiphospholipid syndrome
Left Ventricular Mass Index as an independent predictor of major adverse cardiovascular and cerebrovascular events in patients with SLE
Authors' conclusion
Compared to the control group, patients with SLE showed significantly higher LVM and LVMI. LVMI was identified as an independent risk factor for MACCE in SLE patients.
Study context
- Population
- Patients with SLE and health examination controls, January 2014 to December 2024
- Participants
- 286 vs 64
- Exposure
- SLE vs health examination controls; Left Ventricular Mass Index (LVMI) as predictor of major adverse cardiovascular and cerebrovascular events (MACCE)
- SLEn = 286
- Controln = 64reference
- Outcome
- MACCE
Methodological detailspropensity score matching, multivariate Cox proportional hazards regression, ROC curve analysis
- Propensity score matching
- Multivariate Cox proportional hazards regression
- ROC curve analysis
Main finding
As reported in the abstract
MACCE: independent predictors (multivariate Cox) in SLE cohort
- RVDd independent predictor of MACCE
- p=0.027
- LVMI independent predictor of MACCE
- p=0.017
- Low-density lipoprotein independent predictor of MACCE
- p=0.036
- Optimal LVMI cut-off for predicting adverse outcomes
- 101.7 g/m²
- AUC of LVMI cut-off
- 0.751 (95% CI 0.653 to 0.849)
- Sensitivity
- 76.9%
- Specificity
- 64.6%
Observational data: associations, not effects.
Further findings
Echocardiographic parameters, SLE vs control
- Aortic root
- P = 0.002
- RVDd
- P = 0.038
- Interventricular septal thickness (IVST)
- P = 0.033
- Left ventricular posterior wall thickness (LVPWT)
- P < 0.001
- LVM
- P = 0.025
- LVMI
- P = 0.007
- Left ventricular posterior wall motion amplitude (LVPWMA)
- P = 0.017
- Interventricular septal motion amplitude (IVSMA)
- P = 0.004
Original publication
Left Ventricular Mass Index as an independent predictor of major adverse cardiovascular and cerebrovascular events in patients with SLE. Lupus Sci Med. Published 13 March 2026. doi:10.
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