Lupus & antiphospholipid syndrome
Prevalence of major adverse cardiovascular events among Saudi patients with systemic lupus erythematosus compared with the general population: updates from the national SLE and PURE cohorts
Authors' conclusion
Patients with SLE have a significantly higher risk of developing MACE than the general population. This risk is not well explained by traditional risk factors, which may explain the failure of CVD risk scores to stratify patients with SLE adequately.
Study context
- Population
- Saudi patients with SLE and the general population, 2020 to 2023
- Participants
- 746 vs 488
- Exposure
- Saudi patients with SLE vs general population
- SLEn = 746
- PUREn = 488reference
- Outcome
- Period prevalence of MACE:
- Defined in methods as MI
- Stroke
- Angina
- Follow-up
- 2020 to 2023
Methodological detailstwo national cohorts (Saudi national prospective SLE cohort; PURE-Saudi subcohort), standardised monitoring protocol, logistic regression adjusted for demographics, traditional CV risk factors and SLE diagnosis
- Two national cohorts (Saudi national prospective SLE cohort; PURE-Saudi subcohort)
- Standardised monitoring protocol
- Logistic regression adjusted for demographics, traditional CV risk factors and SLE diagnosis
Main finding
As reported in the abstract
MACE prevalence
P = 0.004
Observational data: associations, not effects.
Further findings
Age
Female
Traditional risk factors (greater in PURE, except hypertension)
Dyslipidaemia
Obesity
Diabetes
Hypertension
Factors associated with major adverse cardiovascular events (MACE) (adjusted logistic regression)
- Age associated with odds of MACE
- P = 0.00
- Lupus diagnosis associated with odds of MACE
- P = 0.00
- Cardiovascular disease (CVD) risk factors not associated with odds of MACE
- P = 0.83
- Older age and lupus diagnosis independently associated with MACE after adjusting for conventional risk factors
Original publication
Prevalence of major adverse cardiovascular events among Saudi patients with systemic lupus erythematosus compared with the general population: updates from the national SLE and PURE cohorts. Lupus Sci Med. Published 24 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →