Lupus & antiphospholipid syndrome
Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) methylenetetrahydrofolate reductase (MTHFR) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study
Authors' conclusion
In conclusion, the TC and the TA MTHFR haplotypes are associated with disease risk; meanwhile, the CC c.+677 MTHFR genotype confers lower cardiometabolic risk in Mexican-mestizo SLE patients.
Study context
- Population
- Unrelated Mexican-mestizo women with systemic lupus erythematosus (SLE) and control subjectsMexican-mestizo women
- Participants
- 199 vs 196
- Comparison
- SLE vs control subjects
- SLEn = 199
- Control subjects (CS)n = 196reference
- Outcome
- Association of MTHFR c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) variants with cardiometabolic risk and clinical disease variables
Methodological detailsFolic acid and homocysteine by immunoassays; genotyping by allelic discrimination
- Folic acid and homocysteine by immunoassays; genotyping by allelic discrimination
Main finding
As reported in the abstract
MTHFR genotypes/haplotypes and CVD and SLE risk
CC c.+677 genotype and low cardiovascular disease (CVD) risk by Castelli index in SLE, OR
0.42
p = .03
TC haplotype and SLE risk, OR
1.3
p = .03
TA haplotype and SLE risk, OR
1.6
p < .01
CC haplotype as non-risk factor for SLE, OR
0.5
p = .01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Folic acid and homocysteine serum levelsSLE vs CS · folic acid | P = 0.15 |
| Folic acid and homocysteine serum levelsSLE vs CS · homocysteine | P = 0.59 |
Folic acid and homocysteine serum levels
- No significant differences between groups
Original publication
Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. Published 23 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →