Lupus & antiphospholipid syndrome
Serum IL-2 levels are associated with disease activity and related to dyslipidaemia and the immunological profile in systemic lupus erythematosus
Authors' conclusion
Significant correlations exist between serum IL-2 levels and markers of inflammation, lipid profile, disease activity and specific autoantibody profiles in patients with SLE.
Study context
- Population
- Well-characterised cohort of patients with systemic lupus erythematosus (SLE)
- Participants
- 235 participants
- Outcome
- Associations between serum IL-2 concentrations (Single Molecule Array (Simoa)) and disease activity, inflammatory markers, autoantibody profiles and cardiovascular and metabolic parameters
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
Associations of serum IL-2 levels (multivariable analyses)
- Significant positive associations with inflammatory markers including CRP and IL-6
- Disease activity (SLEDAI-2K) positively correlated with IL-2 levels
- Positive, significant associations after covariate adjustment with anti-DNA, anti-SSA, anti-SSB, anti-Sm and antiribosome autoantibodies
- Triglycerides positively associated with IL-2
- HDL-cholesterol inversely associated with IL-2
- Multivariable analyses
Observational data: associations, not effects.
Original publication
Serum IL-2 levels are associated with disease activity and related to dyslipidaemia and the immunological profile in systemic lupus erythematosus. Lupus Sci Med. Published 12 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →