Lupus & antiphospholipid syndrome
Association of Ultraviolet B Radiation and Risk of Systemic Lupus Erythematosus Among Women in the Nurses’ Health Studies
Main finding · Overall SLEResult — go to the resultHazard ratio 1.28 95% CI 0.96–1.70Authors' conclusion
Cumulative UV exposure was not associated with SLE risk. Higher UV exposure, however, was associated with increased risk of malar rash at presentation.
Study context
- Population
- US female nurses in the Nurses' Health Study (enrolled 1976) and Nurses' Health Study (NHS) II (enrolled 1989), followed 1976 through 2014 (NHS)/2015 (NHS II)6,054,665 person-years
- Exposure
- Tertiles of time-varying cumulative average ambient ultraviolet (UV) exposure
- Outcome
- Incident systemic lupus erythematosus (SLE) by ACR classification criteria, confirmed by medical record review
Methodological detailstime-varying cumulative average UV exposure, Cox models, adjusted for confounders
- Time-varying cumulative average UV exposure
- Cox models
- Adjusted for confounders
Main finding
Overall SLE
Hazard ratio
1.28
95% CI 0.96–1.70
Highest UV tertilevs Lowest UV tertile
HR 1.28 (95% CI 0.96–1.70)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Malar rash | 1.62 (1.04–2.52) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Association of Ultraviolet B Radiation and Risk of Systemic Lupus Erythematosus Among Women in the Nurses’ Health Studies. Arthritis Care Res (Hoboken). Published 23 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →