Lupus & antiphospholipid syndrome
Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus
Authors' conclusion
In this national sample of adults with SLE, greater neighborhood deprivation was associated with worse physical function and a higher likelihood of short-term functional decline.
Study context
- Population
- Adults (≥18 years) with systemic lupus erythematosus (SLE), ≥2 visits ≥30 days apart and ≥1 functional status (FS) assessment in 2016 to 2022, national RISE registrylongitudinal cohort N = 10,604
- Participants
- 20,620 adults
- Exposure
- Area Deprivation Index (ADI) quintiles of neighborhood socioeconomic disadvantage
- Outcome
- FS score (cross-sectional) and FS decline (longitudinal) by ADI
Methodological detailsnational electronic health record-based registry (RISE), multilevel regression models, ADI quintiles
- National electronic health record-based registry (RISE)
- Multilevel regression models
- ADI quintiles
Main finding
As reported in the abstract
Adjusted mean FS score (higher = worse), cross-sectional
ADI quintile 1
1.53
Adjusted mean · IQR 1.28–1.77
ADI quintile 5
1.90
Adjusted mean · IQR 1.63–2.16
Observational data: associations, not effects.
Further findings
| Outcome | ADI quintile 1 | ADI quintile 5 |
|---|---|---|
| FS decline, longitudinal cohort | 11.4% (IQR 9.3%–13.5%) | 17.0% (IQR 13.7%–20.2%) |
- FS decline, longitudinal cohort — FS decline overall
- 15.7%
- FS decline, longitudinal cohort: only quintiles 1 and 5 printed
Original publication
Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 20 May 2026. doi:10.
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