Lupus & antiphospholipid syndrome
Thrombocytopenia in systemic lupus erythematosus real-world insights from the nationwide Rheumatology Informatics System for Effectiveness (RISE) database
Authors' conclusion
The RISE registry revealed that severe TP was less common in SLE patients from community practice compared to previously reported data from selected tertiary centers. Serologically active SLE, multiple comorbidities, male sex, and non-white race were identified as independent factors associated with TP in this database.
Study context
- Population
- Adults ≥18 years with ≥2 SLE diagnostic codes ≥30 days apart (2016–2022) and a valid complete blood count (CBC) within 1 year of the second SLE code, ACR RISE registry91.2% female
- Participants
- 30,062 adults
- Exposure
- Moderate-to-severe thrombocytopenia (TP) vs other SLE patients
- Outcome
- Prevalence of TP (lowest platelet count within 1 year of second SLE code; mild 100,000-150,000/µL, moderate 50,000-99,000/µL, severe <50,000/µL)
- Follow-up
- Within 1 year of the second SLE code
Methodological detailsregistry-based (ACR RISE EHR-enabled registry), multi-level logistic regression accounting for clustering by practices
- Registry-based (ACR RISE EHR-enabled registry)
- Multi-level logistic regression accounting for clustering by practices
Main finding
As reported in the abstract
Prevalence of TP
TP
9.3%
Severe TP
0.5%
Observational data: associations, not effects.
Further findings
Factors independently associated with moderate-to-severe TP (multivariable logistic regression)
- Sex, race/ethnicity, multiple comorbidities, positive dsDNA and hypocomplementemia independently associated with increased risk of moderate-to-severe TP
Original publication
Thrombocytopenia in systemic lupus erythematosus real-world insights from the nationwide RISE database. Lupus. Published 31 October 2025. doi:10.
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