Lupus & antiphospholipid syndrome
Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus
Authors' conclusion
These results suggest that basophils contribute to the pathogenesis of SLE by promoting B cell differentiation via dsDNA-specific IgE in patients similar to the process described in mouse models.
Study context
- Population
- Patients with SLE and healthy donors (basophils)
Methodological detailshuman samples, co-culture system
- Human samples
- Co-culture system
Main finding
As reported in the abstract
- Serum anti-dsDNA IgE levels in SLE correlated with disease activity
- Healthy donor basophils produced IL-3, IL-4 and TGF-β1 after anti-IgE stimulation
- Co-culture of B cells with anti-IgE-stimulated basophils increased plasmablasts; cancelled by neutralizing IL-4
- After antigen encounter, basophils released IL-4 more quickly than follicular helper T cells
- Basophils from patients with anti-dsDNA IgE increased IL-4 expression on adding dsDNA
Original publication
Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus. Rheumatology (Oxford). Published 22 February 2023. doi:10.
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