Lupus & antiphospholipid syndrome
Association of serum and urinary galectin-3 with renal fibrosis in patients with lupus nephritis: A cross-sectional controlled study
Authors' conclusion
Both sGal-3 and uGal-3 levels are significantly associated with RF severity in LN. The uGal-3 had superior diagnostic performance for moderate/severe IFTA and may be a promising non-invasive RF biomarker in LN.
Study context
- Population
- Patients with lupus nephritis (LN), systemic lupus erythematosus (SLE) without LN, and healthy controls
- Participants
- 150 patients
- Exposure
- LN vs SLE without LN vs healthy controls; mild vs moderate/severe interstitial fibrosis and tubular atrophy (IFTA) within LN
- LNn = 50
- SLE without LNn = 50
- Healthy controlsn = 50reference
- Outcome
- Correlation of sGal-3 and uGal-3 with renal fibrosis (IFTA) severity in LN, and diagnostic performance for moderate/severe IFTA
Methodological detailscontrolled
- Controlled
Main finding
As reported in the abstract
Correlation with IFTA percentage
- sGal-3 vs IFTA %: rho
- 0.76
- uGal-3 vs IFTA %: rho
- 0.81
- P for both correlations
- p < 0.001
- uGal-3 AUC for moderate/severe IFTA
- 0.903
- sGal-3 AUC for moderate/severe IFTA
- 0.801
Observational data: associations, not effects.
Further findings
sGal-3 and uGal-3 levels by group
- LN significantly higher sGal-3 and uGal-3 than other groups
- P < 0.001
sGal-3 and uGal-3 levels by IFTA severity in LN
- Moderate/severe IFTA (≥26%) significantly higher sGal-3 and uGal-3 than mild IFTA (<26%)
- P < 0.001
Multivariable logistic regression for moderate/severe IFTA
- sGal-3 and uGal-3 independently associated with moderate/severe IFTA after adjusting for renal function parameters
Original publication
Association of serum and urinary galectin-3 with renal fibrosis in patients with lupus nephritis: A cross-sectional controlled study. Lupus. Published 28 June 2026. doi:10.
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