Lupus & antiphospholipid syndrome
Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study
Main finding · Severe infections requiring hospitalisationResult — go to the resultOdds ratio 0.69 95% CI 0.34–1.39Authors' conclusion
MMF does not significantly increase the risk of severe infections compared with other immunosuppressants in SLE maintenance therapy.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) on maintenance therapy, Lupus Registry of Nationwide Institutions in Japan
- Participants
- 1,004 patients
- Exposure
- Mycophenolate mofetil (MMF) vs other immunosuppressants in SLE maintenance therapy
- Outcome
- Severe infections requiring hospitalisation
Methodological detailsnationwide, registry-based (LUNA), marginal structural models with stabilised inverse probability of treatment weighting
- Nationwide
- Registry-based (LUNA)
- Marginal structural models with stabilised inverse probability of treatment weighting
Main finding
As reported in the abstract
Odds ratio
0.69
95% CI 0.34–1.39
By group
MMFvs non-MMF
OR 0.69 (95% CI 0.34–1.39)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (mg/day) (95% CI) | |
|---|---|---|
| Change in prednisolone dose | −0.66 (−1.09 to −0.23) | |
| −1.5−1−0.500.5Difference, mg/day (linear scale) |
| Outcome | Difference (points) (95% CI) | |
|---|---|---|
| Organ damage scoreModestly reduced in MMF | −0.19 (−0.37 to −0.01) | |
| Change in disease activity scoreComparable between the groups | −0.10 (−0.74 to 0.55) | |
| −1−0.500.51Difference, points (linear scale) |
All-cause hospitalisation
- Rates comparable between the groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study. RMD Open. Published 22 July 2025. doi:10.
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