Lupus & antiphospholipid syndrome
Mycophenolic acid trough level assessment in patients with lupus nephritis; does it make a difference?
Authors' conclusion
MPA trough levels correlated with disease activity and gastritis in adult LN patients, and this may help to optimize MMF dosage in these patients. However, MPA concentration-effect relationships were not observed in pediatric patients.
Study context
- Population
- Egyptian adults and children with biopsy-proven class III and IV lupus nephritis (LN) maintained on steroid and Mycophenolate Mofetil (MMF) for more than six months
- Participants
- 35 vs 29
- Exposure
- Mycophenolic acid (MPA) trough levels in relation to clinical outcomes and adverse effects, adults vs children
- Adultsn = 35
- Childrenn = 29
- Outcome
- Relationship between MPA trough levels (High-Performance Liquid Chromatography (HPLC)) and clinical outcomes and drug-related adverse effects during LN maintenance
Main finding
As reported in the abstract
Association of MPA trough levels with flares, SLEDAI scores and adverse effects
- Adults: low MPA trough levels associated with flares
- P = 0.027
- Adults: low MPA trough levels associated with SLEDAI scores
- P = 0.019
Observational data: associations, not effects.
Safety
- Adults: high MPA trough levels associated with higher risk of gastritis
- P = 0.007
- Gastritis the most frequent side effect in both age groups
Original publication
Mycophenolic acid trough level assessment in patients with lupus nephritis; does it make a difference? Pediatr Rheumatol Online J. Published 12 March 2025. doi:10.
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