Lupus & antiphospholipid syndrome
Anti-ribosomal-P protein antibodies and systemic lupus erythematosus (SLE): in a cross-sectional study of Danish adult patients with SLE, no significant association is found between anti-ribosomal-P and neuropsychiatric SLE
Authors' conclusion
This study could not confirm a role for anti-Rib-P in the identification of NPSLE. On the other hand, anti-Rib-P was associated with SLE disease activity as well as organ damage.
Study context
- Population
- Danish adult (≥18 years) patients with SLE meeting the ACR 1997 revised classification criteria, population-based cohort
- Participants
- 198 participants
- Outcome
- Prevalence of anti-ribosomal-P protein antibodies (anti-Rib-P)
Methodological detailspopulation-based cohort
- Population-based cohort
Main finding
As reported in the abstract
Anti-Rib-P positive SLE (prevalence)
SLE cohort
7.1%
14 events
Observational data: associations, not effects.
Secondary outcomes
Anti-Rib-P and neuropsychiatric SLE (NPSLE)
- Anti-Rib-P positive patients diagnosed with NPSLE: 3 (21% of patients with NPSLE)
- No statistically significant association between anti-Rib-P and NPSLE
- Mean anti-Rib-P titres did not differ significantly between patients with and without NPSLE
Anti-Rib-P and disease activity (SLEDAI-2K)
- Significant association between anti-Rib-P positivity and SLEDAI-2K score
NPSLE and disease characteristics (stepwise logistic regression)
- NPSLE associated with SLEDAI-2K and SLICC DI score
Original publication
Anti-ribosomal-P protein antibodies and systemic lupus erythematosus (SLE): in a cross-sectional study of Danish adult patients with SLE, no significant association is found between anti-ribosomal-P and neuropsychiatric SLE. Lupus Sci Med. Published 17 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →