Lupus & antiphospholipid syndrome
Clinical features of anti-ribosomal P protein antibodies in systemic lupus erythematosus: A single-center retrospective study in China
Authors' conclusion
Anti-ribosomal P protein antibody-positive SLE is characterized by high disease activity; low C3 levels, anti-U1RNP antibody positivity and rashes are independent risk factors for anti-P antibody positivity in SLE.
Study context
- Population
- In-patients with systemic lupus erythematosus (SLE), single centre in China, June 2009 to December 2022 (median age 35.0 years; 89.9% female)
- Participants
- 388 participants
- Comparison
- Anti-ribosomal P protein antibody-positive vs negative SLE
- Anti-P positiven = 97
- Anti-P negativen = 291reference
- Outcome
- Clinical characteristics and risk factors for anti-ribosomal P protein antibody positivity
Methodological detailssingle-centre, 1:3 gender and age matched
- Single-centre
- 1:3 gender and age matched
Main finding
As reported in the abstract
Clinical characteristics, anti-P positive vs negative
- Anti-P positive had lower C3 and C4 levels, more frequent comorbid rashes and higher disease activity
- Anti-P antibodies correlated with anti-Smith and anti-U1RNP antibodies
- Low C3, anti-U1RNP antibody positivity and rash are independent risk factors for anti-P positivity
Observational data: associations, not effects.
Original publication
Clinical features of anti-ribosomal P protein antibodies in systemic lupus erythematosus: A single-center retrospective study in China. Lupus. Published 2 March 2025. doi:10.
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