Lupus & antiphospholipid syndrome
Unraveling the role of long non-coding RNAs (lncRNAs) and their associated nearby coding genes in the pathogenesis of systemic lupus erythematosus
Authors' conclusion
The current study provides insights into the dysregulation of lncRNAs and nearby mRNAs in SLE, highlighting potential key players in the pathogenesis of the disease.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients (PBMCs); transfected Raji cells
- Outcome
- Differentially expressed lncRNAs and nearby mRNAs in SLE
Methodological detailshigh-throughput sequencing, quantitative real-time PCR (qRT-PCR) verification
- High-throughput sequencing
- qRT-PCR verification
Main finding
As reported in the abstract
Differentially expressed (DE) lncRNAs identified
419
Nearby DE messenger RNAs (mRNAs) identified
337
DE lncRNAs that were lincRNAs and intronic_lncRNAs
More than 67%
Nearby coding genes analysed for lincRNAs
88
Original publication
Unraveling the role of lncRNAs and their associated nearby coding genes in the pathogenesis of systemic lupus erythematosus. Arthritis Res Ther. Published 1 March 2025. doi:10.
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