Lupus & antiphospholipid syndrome
The exploration of shared genes and molecular mechanisms of systemic lupus erythematosus and atherosclerosis
Authors' conclusion
The study provided a new perspective on the common molecular mechanisms between SLE and AS, and the key genes and pathways that were identified as being part of these pathways may offer fresh perspectives and suggestions for further experimental research.
Study context
- Population
- PBMCs from 61 systemic lupus erythematosus (SLE) patients and 20 normal samples (GSE50,772); 69 atherosclerosis (AS) plaque tissue samples and 35 control samples (GSE100,927)two GEO datasets
- Outcome
- Shared genes and pathways of SLE and AS
Methodological detailsanalysis of GEO gene expression datasets (GSE50772, GSE100927), differential expression analysis (limma), gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, PPI and WGCNA, ROC curve validation, miRNA-mRNA network
- Analysis of GEO gene expression datasets (GSE50772, GSE100927)
- Differential expression analysis (limma)
- GO and KEGG enrichment analysis
- PPI and WGCNA
- ROC curve validation
- miRNA-mRNA network
Performance
As reported in the abstract
DEGs identified
246
Upregulated genes
189
Downregulated genes
57
Shared genes identified (PPI/WGCNA intersection, ROC validation; incl. AQP9, CCR1, CD83, CXCL1, FCGR2A)
15
Original publication
The exploration of shared genes and molecular mechanisms of systemic lupus erythematosus and atherosclerosis. Lupus. Published 8 December 2022. doi:10.
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