Lupus & antiphospholipid syndrome
The association of trauma with self-reported flares and disease activity in systemic lupus erythematosus (SLE)
Main finding · Any flareResult — go to the resultOdds ratio 2.27 95% CI 1.24–4.17Authors' conclusion
In this cohort, those with a history of trauma reported more flares and greater disease activity.
Study context
- Population
- Patients with SLE in the California Lupus Epidemiology Study (CLUES)multivariable analyses
- Participants
- 252 patients
- Exposure
- Trauma exposure vs no trauma exposure
- Outcome
- Self-reported flares (any flare; flare with medical care) and disease activity (Systemic Lupus Activity Questionnaire (SLAQ))
Methodological detailsmultivariable regression
- Multivariable regression
Main finding
Any flare
Odds ratio
2.27
95% CI 1.24–4.17
Any traumatic eventvs No trauma
OR 2.27 (95% CI 1.24–4.17)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (CI) | |
|---|---|---|
| Any flare, both BTQ and ACE exposuresBTQ and ACE exposuresvs No trauma | 5.91 (2.21–15.82) | |
| Flare with medical care, both BTQ and ACE exposuresBTQ and ACE exposuresvs No trauma | 4.69 (1.56–14.07) | |
| 0.050.21520Adjusted odds ratio (log scale) |
| Outcome | β (CI) |
|---|---|
| SLAQ scoreAny traumatic event vs No trauma | 2.31 (0.86–3.76) |
| SLAQ scoreBTQ and ACE exposures vs No trauma | 5.22 (3.00–7.44) |
≥1 trauma exposure (excluding serious illness)
- Proportion reporting ≥1 trauma exposure
- 63.4%
Original publication
The association of trauma with self-reported flares and disease activity in systemic lupus erythematosus (SLE). Rheumatology (Oxford). Published 8 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →