Lupus & antiphospholipid syndrome
The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus
Authors' conclusion
Our results demonstrate associations of fatigue and psychosocial factors with physical functioning, reinforcing their relationship with overall health in SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in two demographically distinct cohorts (APPEAL and CLUES)
- Participants
- 451 vs 580
- Exposure
- APPEAL vs CLUES
- APPEALn = 451
- CLUESn = 580
- Outcome
- Perceived physical function (PROMIS Physical Function Short Forms 12a [APPEAL] and 10a [CLUES]) and its associations with fatigue and psychosocial factors
Methodological detailstwo demographically distinct cohorts, multivariable linear regression
- Two demographically distinct cohorts
- Multivariable linear regression
Main finding
As reported in the abstract
Perceived physical function (PROMIS Physical Function T score)
APPEAL
43.6
mean
CLUES
47.2
mean
β
- Greater resilience, per +1 SD (CLUES) · associated with better physical function
- 2.04 (95% CI 0.57–3.50)
- Self-efficacy, high vs low (CLUES) · associated with better physical function
- 13.53 (95% CI 8.69–18.37)
- Better coping, per +1 SD (APPEAL) · associated with better physical function
- 3.15 (95% CI 2.39–3.91)
- Greater learned helplessness, per +1SD (APPEAL) · associated with worse physical function
- −3.88 (95% CI −4.62 to −3.14)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Mean physical function T score | P < 0.05 |
Original publication
The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 3 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →