Lupus & antiphospholipid syndrome

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus

Arthritis Care Res (Hoboken)Published Cross-sectional study

Authors' conclusion

In this large SLE cohort, dietary supplement use was highly prevalent, and nearly one-third of participants had a potential supplement-medication interaction.

Study context

Population
Adults with systemic lupus erythematosus (SLE) in the Approaches to Positive, Patient-Centered Experiences of Aging With Lupus study (Georgians Organized Against Lupus cohort)
Participants
451 adults
Outcome
Prevalence of dietary supplement use
Methodological detailsancillary study of the population-based Georgians Organized Against Lupus cohort, logistic regression
  • Ancillary study of the population-based Georgians Organized Against Lupus cohort
  • Logistic regression

Main finding

As reported in the abstract

Dietary supplement use
Used at least one supplement
80.9%
Used at least two supplements
55.9%
Vitamin D
64.1%
Multivitamins
45.2%
Calcium
29.7%
Vitamin B12
10.6%
Iron
9.3%

Observational data: associations, not effects.

Further findings

Correlates of use of at least two supplements

More common among participants who were older, had higher educational attainment, used at least five prescription medications, or had greater health care use

Safety

Supplement-medication combination with potential for an interaction (NatMed Pro)

Participants taking a potentially interacting combination
29.5%
More frequent with polypharmacy, greater SLE disease damage, and recent primary care visits

Original publication

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 22 September 2026. doi:10.1002/acr.80165

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