Lupus & antiphospholipid syndrome
Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus
Authors' conclusion
In this large SLE cohort, dietary supplement use was highly prevalent, and nearly one-third of participants had a potential supplement-medication interaction.
Study context
- Population
- Adults with systemic lupus erythematosus (SLE) in the Approaches to Positive, Patient-Centered Experiences of Aging With Lupus study (Georgians Organized Against Lupus cohort)
- Participants
- 451 adults
- Outcome
- Prevalence of dietary supplement use
Methodological detailsancillary study of the population-based Georgians Organized Against Lupus cohort, logistic regression
- Ancillary study of the population-based Georgians Organized Against Lupus cohort
- Logistic regression
Main finding
As reported in the abstract
Dietary supplement use
- Used at least one supplement
- 80.9%
- Used at least two supplements
- 55.9%
- Vitamin D
- 64.1%
- Multivitamins
- 45.2%
- Calcium
- 29.7%
- Vitamin B12
- 10.6%
- Iron
- 9.3%
Observational data: associations, not effects.
Further findings
Correlates of use of at least two supplements
- More common among participants who were older, had higher educational attainment, used at least five prescription medications, or had greater health care use
Safety
Supplement-medication combination with potential for an interaction (NatMed Pro)
- Participants taking a potentially interacting combination
- 29.5%
- More frequent with polypharmacy, greater SLE disease damage, and recent primary care visits
Original publication
Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 22 September 2026. doi:10. 1002/ acr. 80165
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