Lupus & antiphospholipid syndrome
Comparison of cardiac MRI features of fibrosis and strain for early cardiac dysfunction assessment in patients with systemic lupus erythematosus and Sjögren’s syndrome
Authors' conclusion
Coexisting SS was independently associated with greater subclinical LV dysfunction and more pronounced myocardial tissue abnormalities in patients with SLE.
Study context
- Population
- Consecutive patients with systemic lupus erythematosus (SLE) with or without coexisting SjD and healthy controls undergoing cardiac MRI
- Participants
- 36 / 36 / 20
- Exposure
- SLE with coexisting SjD vs SLE without SjD vs healthy controls
- SLE with Sjögren's syndrome (SS)n = 36
- SLE without SSn = 36
- Healthy controlsn = 20reference
- Outcome
- Left ventricular (LV) GLS
Methodological detailsconsecutive patients, age- and sex-matched healthy controls, univariable and multivariable linear regression
- Consecutive patients
- Age- and sex-matched healthy controls
- Univariable and multivariable linear regression
Main finding
As reported in the abstract
SLE with SS
−14.21%
interval −16.74–-12.81
SLE without SS
−16.38%
interval −17.73–-14.25
Healthy controls
−17.09%
interval −17.63–-12.97
P = 0.030
Observational data: associations, not effects.
Further findings
Native T1 — SLE with SS vs SLE without SS · three-group comparison
P = 0.016
| Outcome | SLE with SS | SLE without SS | Healthy controls | Estimate | P value |
|---|---|---|---|---|---|
| ECVSLE with SS vs SLE without SS · three-group comparison | 29.00% (interval 27.00–31.00) | 27.50% (interval 25.25–29.00) | 27.00% (interval 25.00–29.00) | P = 0.019 | |
| LGESLE with SS vs SLE without SS · no significant between-group difference | 30.56% | 25.00% | — not stated in the abstract | P = 0.792 | |
| Coexisting SS and LV parameters among all SLE (multivariable linear regression)Impaired GLS · independently associated | β (GLS) −0.211 | P = 0.041 | |||
| Coexisting SS and LV parameters among all SLE (multivariable linear regression)Higher native T1 · independently associated | β (native T1) 0.227 | P = 0.048 | |||
| Coexisting SS and LV parameters among all SLE (multivariable linear regression)Higher ECV · independently associated | β (ECV) 0.268 | P = 0.009 |
— not stated in the abstract
Global circumferential and global radial strain
- Similar between the three groups (p>0.05)
Native T2
- Did not differ significantly among the three groups (p>0.05)
Original publication
Comparison of cardiac MRI features of fibrosis and strain for early cardiac dysfunction assessment in patients with systemic lupus erythematosus and Sjögren’s syndrome. Lupus Sci Med. Published 21 September 2026. doi:10.
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