Lupus & antiphospholipid syndrome
Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan
Authors' conclusion
Patients with low-level proteinuria have a favourable long-term prognosis and are treated with less initial immunosuppressant use, suggesting a distinct clinical subgroup of proliferative lupus nephritis.
Study context
- Population
- Japanese patients with biopsy-confirmed proliferative LN (class III/IV), 11 hospitals
- Participants
- 137 patients
- Exposure
- Low-level proteinuria vs high-level proteinuria in proliferative LN
- Low-level proteinurian = 62
- Outcome
- Kidney failure (KF) or death
- Follow-up
- Median of 93 months
Methodological detailsmulticentre, 11 hospitals, multivariate Cox regression
- Multicentre
- 11 hospitals
- Multivariate Cox regression
Main finding
As reported in the abstract
KF or death
P < 0.001
Observational data: associations, not effects.
Further findings
Initial treatment with GCs alone · baseline
P = 0.04
Long-term prognosis, low-level proteinuria initially treated with glucocorticoids (GCs) alone
- Better long-term prognosis than those with high-level proteinuria
Maintenance therapy
- Similar between groups
Original publication
Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan. Lupus Sci Med. Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →