Lupus & antiphospholipid syndrome
Measurement properties of the FATIGUE-PRO in patients with SLE in real-world settings
Authors' conclusion
The FATIGUE-PRO was demonstrated to be fit-for-purpose in real-world clinical outpatient settings, with strong measurement properties, supporting its use in the assessment of fatigue in SLE.
Study context
- Population
- Patients with SLE aged ≥18 years, real-world clinical outpatient settings (Birmingham, UK, and Düsseldorf, Germany)
- Participants
- 200 vs 234
- Comparison
- Birmingham vs Düsseldorf
- Birminghamn = 200
- Düsseldorfn = 234
- Outcome
- Psychometric properties of the FATIGUE-PRO (physical fatigue, mental and cognitive fatigue, susceptibility to fatigue domains)
Methodological detailscross-sectional, observational, Rasch Measurement Theory, classical test theory, Spearman's rank order correlations
- Cross-sectional
- Observational
- Rasch Measurement Theory
- Classical test theory
- Spearman's rank order correlations
Performance
As reported in the abstract
Measurement properties of the FATIGUE-PRO
Item targeting
82-95%
Ordered thresholds (response scale functioned as intended for most items across all domains)
82-100%
Internal consistency reliability of domain scores
0.90-0.97
Further findings
Construct validity: correlations with other clinical outcome assessments
- Moderate-to-high correlations with other patient-reported outcomes, including Lupus Quality of Life
- Low correlations with Brief Index of Lupus Damage and clinician-reported SLEDAI-2K
Original publication
Measurement properties of the FATIGUE-PRO in patients with SLE in real-world settings. Lupus Sci Med. Published 17 September 2026. doi:10.
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