Lupus & antiphospholipid syndrome
Perceived and Objective Physical Function in 2 United States Population-Based Cohorts of Adults With Systemic Lupus Erythematosus
Authors' conclusion
Our findings show that perceived and objective PF can vary considerably across SLE populations and patient characteristics. Perceived PF may not always reflect objective PF in SLE populations.
Study context
- Population
- Adults with systemic lupus erythematosus (SLE) in 2 US population-based cohorts
- Participants
- 446 vs 173
- Exposure
- APPEAL vs CLUES cohorts; perceived vs objective physical function
- APPEALn = 446
- CLUESn = 173reference
- Outcome
- Perceived PF (PROMIS 12a/10a t-scores) and objective PF (SPPB, 0-12) and their discordance (≥ 2 quartile difference)
Methodological details2 population-based cohorts, multinomial logistic regression
- 2 population-based cohorts
- Multinomial logistic regression
Main finding
As reported in the abstract
Perceived PF (PROMIS t-scores)
APPEAL
41.5
CLUES
47.9
Observational data: associations, not effects.
Further findings
| Outcome | APPEAL | CLUES |
|---|---|---|
| Objective PF (SPPB scores) | 9.0 | 9.4 |
Objective physical function (PF) (SPPB scores)
- No difference after adjustment for disease activity and cumulative disease damage
Factors associated with lower PF across cohorts
- Oldest vs youngest age, PROMIS t-scores
- 40.8 vs 47.4
- Oldest vs youngest age, SPPB scores
- 8.9 vs 9.6
- Black vs White race, PROMIS t-scores
- 40.8 vs 45.6
- Black vs White race, SPPB scores
- 8.9 vs 9.7
- Higher vs lower disease activity, PROMIS t-scores
- 38.1 vs 48.4
- Higher vs lower disease activity, SPPB scores
- 8.7 vs 9.6
Discordant perceived vs objective PF scores
- Participants with discordant scores
- 22.4%
- Older age and higher disease activity independently associated with lower risk of overestimating PF (objective score < perceived score)
Original publication
Perceived and Objective Physical Function in 2 United States Population-Based Cohorts of Adults With Systemic Lupus Erythematosus. J Rheumatol. Published 15 January 2026. doi:10.
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