Lupus & antiphospholipid syndrome

Measuring Frailty in Systemic Lupus Erythematosus

Arthritis Care Res (Hoboken)Published Cohort study

Authors' conclusion

Multiple measures of frailty appear to identify the risk of poor health outcomes.

Study context

Population
Participants with SLE in the California Lupus Epidemiology Study
Exposure
SLICC-FI vs Short Physical Performance Battery (SPPB) vs FRAIL scale vs PROMIS PF-10a for frailty
Outcome
Agreement among frailty measures and association of each with cross-sectional and longitudinal health outcomes
Methodological detailscross-sectional and longitudinal analyses, comparison of frailty measures, logistic and linear regression, Cox proportional hazards analyses
  • Cross-sectional and longitudinal analyses
  • Comparison of frailty measures
  • Logistic and linear regression
  • Cox proportional hazards analyses

Main finding

As reported in the abstract

Percentages of participants identified as frail, range across measures

10.8% to 45.9%

Agreement among classifications, slight to substantial (k)

0.17 to 0.63

Observational data: associations, not effects.

Original publication

Measuring Frailty in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 7 January 2025. doi:10.1002/acr.25479

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