Lupus & antiphospholipid syndrome
Frailty is independently associated with subclinical cardiovascular disease in patients with systemic lupus erythematosus
An erratum to this article was published (RMD Open, 12 Dec 2024 ↗)
Authors' conclusion
SLICC-FI is independently associated with plaque presence.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) who underwent carotid/femoral artery US in the unit between 2016 and 2018 (89.1% women, mean age 46.7±12.6)
- Participants
- 202 patients
- Exposure
- Frailty and subclinical CVD
- Robustn = 39
- Relatively less fitn = 91
- Least fitn = 59
- Frailn = 13
- Outcome
- Atherosclerotic plaque presence (carotid/femoral US) and its association with frailty (SLICC-FI)
Methodological detailslogistic regression adjusted for potential confounders
- Logistic regression adjusted for potential confounders
Main finding
As reported in the abstract
Determinants of atherosclerotic plaque presence, multivariate analysis
Systemic Lupus International Collaborating Clinics-Frailty Index (SLICC-FI), OR per 0.05 point increase (adjusted for traditional and disease-related CVR factors)
OR 1.34
p=0.03
CVR class, OR (adjusted)
OR 5.16
p=0.000
Observational data: associations, not effects.
Further findings
Frailty categories
Atherosclerotic plaque prevalence
- Any plaque
- 52/202 (25.7%)
- Carotid plaque
- 20.8%
- Femoral plaque
- 17.3%
SLICC-FI
- Median (IQR) SLICC-FI
- 0.08 (0.04-0.10)
Univariate associations with plaque presence
- Plaque significantly associated with age, disease duration, smoking, hypertension, systolic BP, dyslipidaemia, Systematic COronary Risk Evaluation (SCORE), CVR class and SLICC-FI
Original publication
Frailty is independently associated with subclinical cardiovascular disease in patients with systemic lupus erythematosus. RMD Open. Published 23 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →