Lupus & antiphospholipid syndrome
Predicting the risk of cardiovascular and cerebrovascular event in systemic lupus erythematosus: a Chinese systemic lupus erythematosus (SLE) treatment and research group study XXVI
Authors' conclusion
We have developed a predictive model that uses clinical indicators to assess the probability of CCE in patients diagnosed with SLE. This model has the ability to precisely predict the risk of CCE in patients with SLE.
Study context
- Population
- Patients with SLE diagnosed <1 year at study start, follow-up >3 years, Chinese SLE Treatment and Research Group cohort93 had cardiovascular and cerebrovascular events (CCEs)
- Participants
- 2,399 patients
- Outcome
- Cardiovascular and cerebrovascular events (CCEs)
Methodological detailscohort-based, Cox proportional hazards regression, least absolute shrinkage and selection operator regression, internal validation
- Cohort-based
- Cox proportional hazards regression
- Least absolute shrinkage and selection operator regression
- Internal validation
Performance
As reported in the abstract
Prediction model for CCE
C index
0.801
Model variables (nine): male gender, smoking, hypertension, age of SLE onset >40, cutaneous involvement, arthritis, anti-β2GP1 antibody positivity, high-dose GC and HCQ usage
9
High-risk group: prognostic index over
0.544
Patients with CCEs during follow-up
93
Original publication
Predicting the risk of cardiovascular and cerebrovascular event in systemic lupus erythematosus: a Chinese SLE treatment and research group study XXVI. RMD Open. Published 23 September 2024. doi:10.
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