Lupus & antiphospholipid syndrome
VPS13C and stimulator of interferon genes (STING) expression in neuropsychiatric systemic lupus erythematosus: unveiling an unbreached territory
Authors' conclusion
The VPS13C expression levels were decreased in patients with NPSLE compared with patients without NPSLE, while STING expression levels showed higher levels in NPSLE. Both were associated with the MRI findings. To distinguish patients with NPSLE from those without it, the VPS13C assessment performed better.
Study context
- Population
- Patients with SLE with and without neuropsychiatric symptoms and healthy controls
- Participants
- 100 patients
- Comparison
- SLE vs healthy controls
- SLEn = 50
- Controln = 50reference
- Outcome
- VPS13C gene and STING expression levels
Methodological detailsage-matched and sex-matched healthy controls, quantitative real-time PCR
- Age-matched and sex-matched healthy controls
- Quantitative real-time PCR
Main finding
As reported in the abstract
- SLE vs Control: P < 0.001
- SLE vs Control: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | NPSLE | Non-NPSLE |
|---|---|---|
| NPSLE classification and positive MRI | 22% | 78% |
| Positive MRI | 55% | 7.7% |
VPS13C and STING by MRI status
- Both markers showed significant differences between MRI-positive and MRI-negative groups
Discrimination of neuropsychiatric SLE (NPSLE) from non-NPSLE
- VPS13C cut-off
- 0.225
- STING cut-off
- 3.15
- Both markers distinguished NPSLE from non-NPSLE; VPS13C performed better
Original publication
VPS13C and STING expression in neuropsychiatric systemic lupus erythematosus: unveiling an unbreached territory. Lupus Sci Med. Published 20 September 2024. doi:10.
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