Lupus & antiphospholipid syndrome
Unveiling the clinical and genetic impact of neuropsychiatric involvement in systemic lupus erythematosus
Authors' conclusion
Neuropsychiatric involvement in SLE increases clinical manifestations and extends organ damage beyond the nervous system, with NPSLE-related genetic variants highlighting their potential functional roles in various brain regions.
Study context
- Population
- Korean patients with SLE in a prospective lupus cohort
- Participants
- 271 / 84 / 26 / 934
- Exposure
- Neuropsychiatric systemic lupus erythematosus (NPSLE) vs non-NPSLE
- NPSLEn = 271
- Seizuren = 84
- Psychosisn = 26
- Non-NPSLEn = 934reference
- Outcome
- Clinical features and organ damage, NPSLE vs non-NPSLE
Methodological detailsgenome-wide genotyping with imputation, functional analyses
- Genome-wide genotyping with imputation
- Functional analyses
Main finding
As reported in the abstract
Odds ratio
1.49
P = 3.28×10-17
total SLICC/ACR DI (SDI) score
Odds ratio
1.22
P = 7.61×10-5
non-NP SDI score
Observational data: associations, not effects.
Further findings
GWAS: NPSLE-associated loci
- NPSLE-associated loci at suggestive significance (p<5×10⁻⁶)
- nine
- Nearest mapped genes exclusively expressed in the brain
- adjusted p=5.28×10-4
- Particularly basal ganglia, cortex and hippocampus
- adjusted p<0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Unveiling the clinical and genetic impact of neuropsychiatric involvement in systemic lupus erythematosus. RMD Open. Published 7 October 2025. doi:10.
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