Lupus & antiphospholipid syndrome
Dyspigmentation and scarring in cutaneous lupus erythematosus
Authors' conclusion
Our results reflect important differences in the CLE categories and CCLE subtypes which may be helpful for clinicians and patients as they navigate the course of the disease.
Study context
- Population
- Patients in the University of Pennsylvania cutaneous lupus erythematosus (CLE) database, divided by CLE category and CCLE subtype
- Exposure
- CLE categories and CCLE subtypes
- Outcome
- Dyspigmentation and scarring (CLE Disease Area and Severity Index damage score) and their correlation
- Follow-up
- Visit with highest dyspigmentation
Methodological detailssingle-centre CLE database review
- Single-centre CLE database review
Main finding
As reported in the abstract
Dyspigmentation and scarring across CLE categories and CCLE subtypes
- Dyspigmentation and scarring significantly differed between CLE categories and CCLE subtypes
- Across categories, CCLE had the highest medians for dyspigmentation and scarring
- Across CCLE subtypes, discoid lupus erythematosus (DLE) had the highest medians for dyspigmentation and scarring
- Positive dyspigmentation–scarring correlations in CCLE, DLE and LE panniculitis
Observational data: associations, not effects.
Original publication
Dyspigmentation and scarring in cutaneous lupus erythematosus. Lupus Sci Med. Published 6 October 2025. doi:10.
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