Lupus & antiphospholipid syndrome
Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China
Authors' conclusion
CLE and iCLE are two distinct disease states, and the selection of broad or narrow CLE definitions should be emphasised in scientific reports.
Study context
- Population
- Patients with lupus erythematosus (isolated cutaneous lupus erythematosus (iCLE) and SLE) from the Lupus Erythematosus Multicenter Case-control Study in Chinese populations (LEMCSC)
- Participants
- 1,865 / 1,648 / 232 / 1,330 / 160 / 546 / 311 / 262 / 45
- Exposure
- Comparison of demographic and clinical features among lupus erythematosus subtypes
- SLEn = 1,865
- Cutaneous lupus erythematosus (CLE)n = 1,648
- iCLEn = 232
- Acute cutaneous lupus erythematosus (ACLE)n = 1,330
- Subacute cutaneous lupus erythematosus (SCLE)n = 160
- Chronic cutaneous lupus erythematosus (CCLE)n = 546
- Discoid lupus erythematosus (DLE)n = 311reference
- Chilblain lupus erythematosus (CHLE)n = 262
- Lupus erythematosus profundus (LEP)n = 45
- Outcome
- Demographic and clinical differences among LE subtypes
Methodological detailsmulticentre, real-world
- Multicentre
- Real-world
Main finding
As reported in the abstract
- Demographic characteristics, systemic involvement, mucocutaneous manifestations and autoantibodies were significantly different among the groups
Observational data: associations, not effects.
Further findings
| Outcome | CHLE | LEP |
|---|---|---|
| Autoantibody positive rates, CCLE subtypes | ||
| anti-SSA/Ro60 positive rate | 71% | — not stated in the abstract |
| anti-SSA/Ro52 positive rate | 42.4% | — not stated in the abstract |
| Antinucleosome antibody positive rate | — not stated in the abstract | 31.1% |
— not stated in the abstract
Autoantibody positive rates, CCLE subtypes
- CHLE had significantly higher positive rates of anti-SSA/Ro60 and anti-SSA/Ro52 than DLE; LEP associated with higher antinucleosome positive rate
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China. Lupus Sci Med. Published 20 March 2023. doi:10.
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