Lupus & antiphospholipid syndrome
Risk of End‐Stage Renal Disease in Patients With Systemic Lupus Erythematosus and Diabetes Mellitus: A Danish Nationwide Cohort Study
Main finding · ESRDResult — go to the resultMultivariable-adjusted HR 3.3 95% CI 1.8–6.1Authors' conclusion
Our findings indicate that SLE patients with DM have a markedly higher risk of developing ESRD compared with SLE patients without DM.
Study context
- Population
- Adult patients diagnosed with systemic lupus erythematosus (SLE) in Denmark between January 1, 1996, and July 31, 2018
- Participants
- 3,178 patients
- Exposure
- SLE with diabetes mellitus (DM) vs SLE without DM
- SLE-DMn = 290
- SLE-non-DMn = 2,859reference
- Outcome
- ESRD (first registration of dialysis, renal transplant, or terminal renal insufficiency)
Methodological detailsinception cohort, Danish National Patient Registry, multivariable-adjusted, stratified analyses
- Inception cohort
- Danish National Patient Registry
- Multivariable-adjusted
- Stratified analyses
Main finding
ESRD
Multivariable-adjusted HR
3.3
95% CI 1.8–6.1
SLE-DMvs SLE-non-DM
multivariable-adjusted HR 3.3 (95% CI 1.8–6.1)
As reported in the abstract
Observational data: associations, not effects.
Further findings
End-stage renal disease (ESRD), stratified multivariable-adjusted analyses
- DM increased the rate of ESRD in women and men, patients ≥50 years old at baseline, those with low educational level at baseline, and those with concomitant hypertension
Original publication
Risk of End‐Stage Renal Disease in Patients With Systemic Lupus Erythematosus and Diabetes Mellitus: A Danish Nationwide Cohort Study. Arthritis Care Res (Hoboken). Published 20 March 2023. doi:10.
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