Lupus & antiphospholipid syndrome
Lupus Flares: More Common in Dialysis Patients Than in Post–Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis
Authors' conclusion
Extrarenal lupus flares can still occur in more than one-third of patients with ESRD receiving RRT. Dialysis patients have a higher flare risk than those after KT, with comparable flare risk among patients receiving HD and PD.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and end-stage renal disease (ESRD) undergoing renal replacement therapy (RRT) (hemodialysis (HD), peritoneal dialysis (PD), kidney transplant (KT)); literature 1973–202357 studies
- Comparison
- SLE flares after ESRD/RRT: HD vs PD, and HD/PD vs KT
- Outcome
- Frequency of SLE flares after ESRD or RRT
Methodological detailsrandom effect models, I2 heterogeneity statistics
- Random effect models
- I2 heterogeneity statistics
Pooled result
As reported in the abstract
Extrarenal SLE flare
Odds ratio (95% CI)P value
PDvs HD7 studies
1.05(0.57–1.94)
PD/HDvs KT4 studies
4.36(1.66–11.47)
P = 0.0028- ESRD patients with ≥1 extrarenal flare after RRT
- 35.9%
Further pooled results
- Lupus nephritis (LN) recurrence after KT
- 3.39%
- LN recurrence after KT: LN recurrence analysed in 29 studies
Original publication
Lupus Flares: More Common in Dialysis Patients Than in Post–Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis. Arthritis Care Res (Hoboken). Published 13 March 2025. doi:10.
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