Comprehensive analysis of disease activity, neuropsychiatric symptoms, imaging features and risk factors for seizure in hospitalized patients with juvenile-onset neuropsychiatric systemic lupus erythematosus
Authors' conclusion
These findings contribute to the early detection of potential NPSLE patients and help clinicians to pay attention to potentially high-risk populations for NPSLE.
Study context
- Population
- Patients admitted to the Xiangya Second Hospital of Central South University, January 2010 to December 2023
- Participants
- 89 / 219 / 150
- Exposure
- Juvenile-onset neuropsychiatric systemic lupus erythematosus (NPSLE) vs juvenile-onset non-NPSLE and vs adult-onset NPSLE
- Juvenile-onset NPSLEn = 89
- Juvenile-onset non-NPSLEn = 219reference
- Adult-onset NPSLEn = 150reference
- Outcome
- Clinical characteristics of juvenile-onset NPSLE
Methodological detailssingle-centre, cluster analysis, multivariate logistic regression, synthesis with case reports from databases
- Single-centre
- Cluster analysis
- Multivariate logistic regression
- Synthesis with case reports from databases
Main finding
As reported in the abstract
- Vs juvenile non-NPSLE: juvenile-onset NPSLE had higher rates of myositis, cardiac involvement, overlap syndrome, anti-SSA antibodies and ANCA positivity, and higher disease activity scores
- Vs adult-onset NPSLE: juvenile-onset NPSLE had greater likelihood of headaches, seizures, movement disorders and renal involvement, higher positive rates of anti-dsDNA and anti-nucleosome antibodies and higher disease activity scores, and lower probability of polyneuropathy
Observational data: associations, not effects.
Further findings
Risk factors for seizures in juvenile-onset NPSLE
- Disease activity was an independent risk factor for seizures
- Multivariate logistic regression
Original publication
Comprehensive analysis of disease activity, neuropsychiatric symptoms, imaging features and risk factors for seizure in hospitalized patients with juvenile-onset neuropsychiatric systemic lupus erythematosus. Semin Arthritis Rheum. Published 5 August 2025. doi:10.
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