Assessment of myelin oligodendrocyte glycoprotein antibodies and magnetic resonance spectroscopy in childhood-onset systemic lupus erythematosus
Authors' conclusion
There was no association of MOG-Ab with cSLE, whether NP manifestations were present or not.
Study context
- Population
- Childhood-onset systemic lupus erythematosus (SLE) (mean age 16.22±3.22 years) and healthy children45 cSLE, 28 healthy
- Participants
- 9 / 36 / 28
- Exposure
- cSLE vs healthy children
- NPSLEn = 9
- non-NPSLEn = 36
- Healthyn = 28reference
- Outcome
- MOG-Ab detection; MRS metabolite peaks (choline, NAA, creatine, NAA/creatine, choline/creatine)
Main finding
As reported in the abstract
MOG-Ab
- Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) was not detected in cSLE or in healthy group
Observational data: associations, not effects.
Further findings
Magnetic resonance spectroscopy (MRS) metabolites (choline, N-acetyl aspartate (NAA), creatine, NAA/creatine, choline/creatine), non-NPSLE vs healthy
- No significant difference between non-NPSLE and healthy
- 20 non-NPSLE and 20 healthy met MRS imaging standards
Original publication
Assessment of myelin oligodendrocyte glycoprotein antibodies and magnetic resonance spectroscopy in childhood-onset systemic lupus erythematosus. Clin Exp Rheumatol. Published 22 June 2022. doi:10.
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