Lupus & antiphospholipid syndrome
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis
Authors' conclusion
Our study found overall and especially in women that higher SUA in LN patients were associated with increased risk of renal progression. Meta-analysis yielded consistent results.
Study context
- Population
- Biopsy-proven lupus nephritis (LN) patients, Southern Chinese populationbiopsy-proven LN
- Participants
- 123 patients
- Comparison
- Higher vs lower serum uric acid level in biopsy-proven LN
- Hyperuricemian = 72
- Outcome
- Progression of LN (renal outcome)
Methodological detailsretrospective observational, Cox proportional hazard regression, restricted cubic spline analyses
- Retrospective observational
- Cox proportional hazard regression
- Restricted cubic spline analyses
Pooled result
As reported in the abstract
LN progression
Hazard ratio (95% CI)
Increased serum uric acid level (continuous variable)
1.003(1.001–1.005)
Increased serum uric acid level (categorical variable)
1.780(1.201–2.639)
Further pooled results
Kidney function progression in LN (meta-analysis)
| WMD (95% CI) | ||
|---|---|---|
| Continuous SUA | 1.73 (0.97–2.49) | |
| −10123Difference (linear scale) |
| OR (95% CI) | ||
|---|---|---|
| Categorical SUA | 1.55 (1.20–2.01) | |
| 0.512Odds ratio (log scale) |
LN progression in men (subgroup)
- Relationship not maintained in men
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between serum uric acid level and systemic lupus erythematosus kidney outcome: An observational study in Southern Chinese population and a meta-analysis. Lupus. Published 17 November 2022. doi:10.
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