Lupus & antiphospholipid syndrome
Elevated serum uric acid is associated with renal arteriolopathy and predict poor outcome in patients with lupus nephritis
Main finding · ESRD or death (Cox regression, adjusted)Result — go to the resultHazard ratio 1.100 95% CI 1.023–1.253Authors' conclusion
SUA levels are directly associated with renal arteriolar damage and poor prognosis in LN patients. Hyperuricaemia is an important predictor for poor prognosis in patients with LN.
Study context
- Population
- Patients with biopsy-proven Lupus Nephritis (LN), Affiliated Hospital of Qingdao University, January 2013–June 2021biopsy-proven LN
- Participants
- 194 patients
- Exposure
- LN with hyperuricaemia vs LN without hyperuricemia; Serum uric acid (SUA) as continuous predictor
- Outcome
- Death or ESRD
Methodological detailssingle-centre, biopsy-proven, logistic and Cox regression
- Single-centre
- Biopsy-proven
- Logistic and Cox regression
Main finding
ESRD or death (Cox regression, adjusted)
Hazard ratio
1.100
95% CI 1.023–1.253
P = 0.035
SUA
HR 1.100 (95% CI 1.023–1.253); P = 0.035
Per 100 μmol/L increase, as printed
As reported in the abstract
- Female
- HR=3.180; 95% CI: 1.216-8.313; p=0.018
- White blood cell count
- HR=1.111; 95% CI: 1.027-1.202; p=0.009
- Serum creatinine
- HR=1.800; 95% CI: 1.348-2.404; p<0.001
- Renal arteriolar damage
- HR=3.117; 95% CI: 1.022-9.511; p=0.046
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Arteriolar damage (logistic regression)Per 100 μmol/L increase; risk raised by 53.8% · adjusted for haemoglobin, serum creatinine and ESR | 1.538 (1.147–2.063) | P = 0.004 | |
| 0.512Hazard ratio (log scale) |
Clinical and histologic features, hyperuricaemia vs without
- Hyperuricaemia: higher BP, hyperlipidaemia, lower eGFR, haemoglobin and serum albumin, worse renal arteriolar damage and proteinuria, higher SLEDAI score, activity index and chronicity index
- P < 0.05
Original publication
Elevated serum uric acid is associated with renal arteriolopathy and predict poor outcome in patients with lupus nephritis. Clin Exp Rheumatol. Published 17 January 2023. doi:10.
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