Lupus & antiphospholipid syndrome
Total Tubulointerstitial Score: a simple and effective predictor of long-term mortality and adverse renal outcomes in lupus nephritis
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.50 95% CI 1.02–2.22Authors' conclusion
TTS provides a comprehensive assessment of renal tubulointerstitial lesions and is a simple and effective predictor of long-term mortality and adverse renal outcomes in LN.
Study context
- Population
- Patients with lupus nephritis (LN) diagnosed from 1996 to 2018 at the First Affiliated Hospital of Sun Yat-sen University
- Participants
- 832 patients
- Exposure
- TTS >2 vs TTS ≤2
- Outcome
- Long-term all-cause mortality and adverse renal outcomes
Methodological detailssingle-centre, Kaplan-Meier survival curves, multivariate Cox regression
- Single-centre
- Kaplan-Meier survival curves
- Multivariate Cox regression
Main finding
All-cause mortality
Hazard ratio
1.50
95% CI 1.02–2.22
P = 0.039
TTS >2vs TTS ≤2
HR 1.50 (95% CI 1.02–2.22); P = 0.039
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Adverse renal outcomesMultivariate Cox analysis; independently associated | 1.63 (1.05–2.52) | P = 0.030 | |
| 0.20.5125Hazard ratio (log scale) |
Correlates of TTS
- TTS negatively correlated with eGFR, haemoglobin and serum albumin; positively correlated with proteinuria (Pearson)
- TTS significantly higher in proliferative LN
Original publication
Total Tubulointerstitial Score: a simple and effective predictor of long-term mortality and adverse renal outcomes in lupus nephritis. Lupus Sci Med. Published 20 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →