Lupus & antiphospholipid syndrome
Tubulointerstitial inflammation driving interstitial fibrosis and tubular atrophy predicts poor renal outcome in refractory lupus nephritis
Authors' conclusion
TII predicts the development of IF/TA in LN and independently from glomerulosclerosis is associated with progression to ESKD.
Study context
- Population
- Lupus nephritis (LN) patients with ≥2 biopsies from 1994 to 2018; 84% female, age 25 (+/−12) years at diagnosis; 90% class III or IV proliferative LN with or without class V on initial biopsymedian follow-up 11 (6–16) years
- Participants
- 104 patients
- Outcome
- ESKD and progression of IF/TA
Methodological detailsrepeat kidney biopsies, multiplex immunohistochemistry
- Repeat kidney biopsies
- Multiplex immunohistochemistry
Main finding
As reported in the abstract
Patients developing end-stage kidney disease (ESKD)
47
Persistent tubulointerstitial inflammation (TII) ≥ 25% in the absence of chronicity, only histological predictor of ESKD: OR
4.13 (1.06, 16.06) (95% CI)
Observational data: associations, not effects.
Further findings
TII composition (multiplex immunohistochemistry)
- TII occurred as CD8 T cell-mediated tubulitis or as organized T and B cell rich infiltrates reminiscent of tertiary lymphoid structures
Original publication
Tubulointerstitial inflammation driving interstitial fibrosis and tubular atrophy predicts poor renal outcome in refractory lupus nephritis. Rheumatology (Oxford). Published 10 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →