Lupus & antiphospholipid syndrome
Association of genetic variation on X chromosome with systemic lupus erythematosus in both Thai and Chinese populations
Authors' conclusion
Our study confirmed previous SLE associations in X chromosome, and identified two loci suggestively associated with SLE. More importantly, our study indicated a higher risk of SLE for females with trisomy X.
Study context
- Population
- Thai and Chinese populations: patients with SLE and controls
- Comparison
- SLE vs controls
- Outcome
- Association of X chromosome genetic variants with SLE, and influence of trisomy X
Methodological detailscase-control, sex-specific analyses with meta-analysis, two populations (Thai and Chinese)
- Case-control
- Sex-specific analyses with meta-analysis
- Two populations (Thai and Chinese)
Pooled result
As reported in the abstract
X chromosome loci associated with SLE
- Two loci suggestively associated with SLE
- 2
Further pooled results
Trisomy X (47,XXX) in females · 5 of 2231 females with SLE
two-sided exact binomial test P=0.002
Original publication
Association of genetic variation on X chromosome with systemic lupus erythematosus in both Thai and Chinese populations. Lupus Sci Med. Published 8 March 2024. doi:10.
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