Lupus & antiphospholipid syndrome
Genetic susceptibility and clinical features of CYP2D6 associated with systemic lupus erythematosus in a Chinese population
Main finding · CYP2D6 (rs1065852) distribution / allele mutation rateResult — go to the resultRelative risk 0.802Authors' conclusion
The metabolic enzyme CYP2D6 may be used as susceptibility gene for predicting systemic lupus erythematosus and are correlated with CRP and other indicators.
Study context
- Population
- Chinese Systemic Lupus Erythematosus (SLE) patients, Nanfang Hospital Affiliated to Southern Medical University, 2021–2023
- Participants
- 137 patients50 single nucleotide polymorphisms (SNPs)
- Exposure
- SLE patients' CYP2D6 (rs1065852) genotype/allele frequencies vs East Asian population and kidney transplant recipients
- SLEn = 137
- Outcome
- CYP2D6 (rs1065852) distribution / allele mutation rate
Methodological detailssingle-centre, genetic association study
- Single-centre
- Genetic association study
Main finding
As reported in the abstract
Relative risk
0.802
P = 0.0355
By group
SLE
63.6%
Observational data: associations, not effects.
Further findings
Association of rs1065852 variant genotype (GA + AA) with laboratory indicators
- Variant genotype (GA + AA) significantly associated with lower CRP, higher HGB and higher HDL-C (p < 0 0.05)
Original publication
Genetic susceptibility and clinical features of CYP2D6 associated with systemic lupus erythematosus in a Chinese population. Lupus. Published 17 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →