Lupus & antiphospholipid syndrome
Impact of an online lupus self-management programme in an established, population-based cohort of adults with diagnosed SLE: a mixed-methods study
Authors' conclusion
SELF showed promising results for reducing disease activity, pain and fatigue among specific subgroups of participants with SLE.
Study context
- Population
- Adults with SLE from the population-based Georgians Organized Against Lupus (GOAL) cohort, Georgia12 also interviewed
- Participants
- 221 adults
- Outcome
- Patient-reported outcomes:
- Disease activity
- Pain
- Fatigue
- Self-efficacy
- Follow-up
- 90-day follow-up
Methodological detailsconvergent mixed-methods design, RE-AIM evaluation framework, single-group pre-post
- Convergent mixed-methods design
- RE-AIM evaluation framework
- Single-group pre-post
Main finding
As reported in the abstract
Disease activity change in subgroups
Black participants (n=193): significantly lower disease activity, 95% CI
−1.59 to −0.04
High fatigue (n=164): significantly lower disease activity, 95% CI
−1.85 to −0.11
Below 100% federal poverty level (n=74): significantly lower disease activity, 95% CI
−3.44 to −0.18
Further findings
Self-efficacy in managing medications · 90-day follow-up
| Mean reduction (95% CI) | ||
|---|---|---|
| SELF | −1.38 (−2.50 to −0.26) | |
| −3−2−101Difference (linear scale) |
- Self-efficacy in managing medications: Cohen's d=−0.14; qualitative data suggested greater awareness of skill gaps
Fatigue subgroups, multiple measures · 90-day follow-up
- High-fatigue participants improved on multiple measures; low-fatigue group showed unexpected declines that may reflect baseline confounding
Original publication
Impact of an online lupus self-management programme in an established, population-based cohort of adults with diagnosed SLE: a mixed-methods study. Lupus Sci Med. Published 7 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →