Lupus & antiphospholipid syndrome
Absolute risk estimation of new-onset proteinuria in patients with systemic lupus erythematosus: a Danish nationwide cohort study
Authors' conclusion
Large differences in absolute risk estimates for new-onset proteinuria were identified.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from Danish SLE centres, mainly Caucasian (94%) women (88%), mean age at inclusion 34.6 years
- Participants
- 586 patients
- Outcome
- New-onset proteinuria (absolute risk)
Methodological detailsmultivariate Cox regression
- Multivariate Cox regression
Main finding
As reported in the abstract
New-onset proteinuria: risk factors and absolute risk
- Cumulative prevalence of proteinuria
- 40%
- Discoid rash, HR
- 0.42 (p=0.01)
- Lymphopenia, HR
- 1.77 (p=0.005)
- Men with lymphopenia, 1-year risk (debut at 20, 30, 40 or 50 years)
- 9-27%
- Men with lymphopenia, 5-year risk
- 34-75%
- Men with lymphopenia, 10-year risk
- 51-89%
- Women with lymphopenia, 1-year risk
- 3-9%
- Women with lymphopenia, 5-year risk
- 8-34%
- Women with lymphopenia, 10-year risk
- 12-58%
Observational data: associations, not effects.
Original publication
Absolute risk estimation of new-onset proteinuria in patients with systemic lupus erythematosus: a Danish nationwide cohort study. Clin Exp Rheumatol. Published 7 December 2022. doi:10.
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