Lupus & antiphospholipid syndrome
Lupus activity and outcomes in lupus patients undergoing maintenance dialysis
Authors' conclusion
The proportion of lupus patients off-treatment increases after MD initiation, but non-severe and severe lupus flares continue to occur, mainly during the first year.
Study context
- Population
- Lupus patients who started maintenance dialysis between 2008 and 2011, REIN registry, France national health data121 females and 16 males
- Participants
- 137 patients
- Outcome
- Proportion of patients 'off-treatment' (0-5 mg/d of corticosteroids, without any immunosuppressive therapy) after the start of maintenance dialysis
Methodological detailsnational, registry-based (REIN), 5-year follow-up
- National
- Registry-based (REIN)
- 5-year follow-up
Main finding
As reported in the abstract
Proportion of patients 'off-treatment'
Off-treatment at dialysis initiation
67.7%
95% CI 61.8, 73.8%
Off-treatment at 1 year
76.0%
95% CI 73.3, 78.8
Off-treatment at 3 years
83.4%
95% CI 81.0, 85.9%
Observational data: associations, not effects.
Further findings
Lupus flares (mainly in the first year after dialysis initiation) · 12 months
- Non-severe lupus flare
- 51.6%
- Severe lupus flare
- 11.6%
Safety
Hospitalisation for CV events or infections · 12 months
- Hospitalised for CV events
- 42.2% (95% CI: 32.9, 50.3%)
- Hospitalised for infections
- 23.7% (95% CI: 16.0, 30.7%)
Original publication
Lupus activity and outcomes in lupus patients undergoing maintenance dialysis. Rheumatology (Oxford). Published 20 June 2023. doi:10.
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