Lupus & antiphospholipid syndrome
Investigating the potential associated factors and developing a risk model for interstitial lung disease in Chinese patients with systemic lupus erythematosus
Authors' conclusion
Age, female sex, renal involvement, C3 level, IgM level, and a positive anti-nRNP result are independent risk factors for ILD.
Study context
- Population
- Chinese patients with systemic lupus erythematosus (SLE)
- Participants
- 40 vs 40
- Comparison
- SLE with interstitial lung disease (ILD) vs SLE without ILD
- SLE-ILDn = 40
- SLE-non-ILDn = 40reference
- Outcome
- Risk factors for ILD in SLE
Methodological detailsmultivariate logistic regression, ROC curve analysis
- Multivariate logistic regression
- ROC curve analysis
Main finding
As reported in the abstract
Independent ILD risk factors in SLE (multivariate logistic regression)
- Older age: OR 1.212
- p < 0.001
- Female sex: OR 37.075
- p = 0.022
- Renal involvement: OR 20.039
- p = 0.011
- C3 level: OR 63.126
- p = 0.037
- IgM level: OR 5.082
- p = 0.005
- Positive anti-nRNP: OR 19.886
- p = 0.003
Observational data: associations, not effects.
Further findings
ILD risk model (combined independent factors), ROC analysis
- AUC
- 0.887 (95% CI 0.815-0.960)
Univariate differences, SLE-ILD vs SLE-non-ILD
- Older age in SLE-ILD
- P < 0.001
- Dry cough more in SLE-ILD
- P = 0.006
- Velcro-like crackles more in SLE-ILD
- P = 0.021
- Raynaud's phenomenon more in SLE-ILD
- P = 0.040
- Elevated C3 in SLE-ILD
- P = 0.044
- Lower SLEDAI score in SLE-ILD
- P = 0.013
- Lower CD3 cell count in SLE-ILD
- P = 0.043
Original publication
Investigating the potential associated factors and developing a risk model for interstitial lung disease in Chinese patients with systemic lupus erythematosus. Lupus. Published 20 June 2023. doi:10.
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