Lupus & antiphospholipid syndrome
Post-traumatic stress disorder and systemic lupus erythematosus: insights from a systematic review
Authors' conclusion
PTSD is strongly associated with an increased risk of developing SLE.
Study context
- Population
- Studies assessing the PTSD-SLE relationship; SLE patients, predominantly females in USA-based studies
- Participants
- 11,614 participants7 studies
- Comparison
- Post-traumatic stress disorder (PTSD) vs no PTSD, risk of developing SLE
- Outcome
- Relationship between PTSD and the risk of developing SLE
Methodological detailsPRISMA, PubMed and Scopus searched to 1 January 2025, GWAS-based genetic overlap analysis
- PRISMA
- PubMed and Scopus searched to 1 January 2025
- GWAS-based genetic overlap analysis
Pooled result
As reported in the abstract
PTSD and risk of SLE
SLE patients with comorbid PTSD
1325
11.4%
Studies reporting at least a 2-fold increased risk of SLE in PTSD patients
3
Further pooled results
Comorbidities in PTSD-SLE patients
- Depression and anxiety were common comorbidities
- n = 2 studies
Shared genetic predisposition (GWAS genes)
- No significant common genetic variants between PTSD and SLE
Original publication
Post-traumatic stress disorder and systemic lupus erythematosus: insights from a systematic review. Rheumatology (Oxford). Published 21 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →