Lupus & antiphospholipid syndrome
Association of a self-report screening tool for sarcopenia (SARC-F) with functional status outcomes in systemic lupus erythematosus
Authors' conclusion
Among women with SLE, SARC-F was significantly associated with multiple functional status measures, suggesting that SARC-F is a promising screening tool for detection of sarcopenia among women with SLE.
Study context
- Population
- Women ≥18 years of age with systemic lupus erythematosus (SLE)
- Participants
- 47 women
- Exposure
- SARC-F ≥4 vs SARC-F <4
- SARC-F ≥4n = 16
- Outcome
- Association of SARC-F (continuous and dichotomous) with self-report functional measures and performance-based measures of physical function
Main finding
As reported in the abstract
SARC-F ≥4
34%
16
- SARC-F ≥4 had worse organ damage and functional measures than SARC-F <4
- all p < 0.01
- SARC-F continuous scores correlated with hand grip strength, 4-m walk test and self-report disability
- all p < 0.01
- SARC-F continuous scores associated with functional status measures, incl. after adjustment
- P < 0.01 to p = 0.046
- Dichotomous SARC-F associated with 4-m walk test, incl. in adjusted models
- P < 0.01
Observational data: associations, not effects.
Original publication
Association of a self-report screening tool for sarcopenia (SARC-F) with functional status outcomes in systemic lupus erythematosus. Lupus. Published 20 April 2025. doi:10.
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