Lupus & antiphospholipid syndrome
Blunted cerebral oxygenation during exercise in systemic lupus erythematosus patients
Authors' conclusion
Our data show that SLE patients even without overt neuropsychiatric manifestations exhibit a blunted increase in cerebral-O2Hb during a submaximal exercise stimulus.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients without known neuropsychiatric manifestations and age-matched controls
- Participants
- 26 vs 27
- Comparison
- SLE patients without known neuropsychiatric manifestations vs age-matched controls
- SLEn = 26
- Controlsn = 27reference
- Outcome
- Cerebral oxygenation (O2Hb, HHb, total-haemoglobin (tHb) by near-infrared-spectroscopy (NIRS)) during 3-min submaximal (30%) handgrip exercise
Methodological detailsage-matched controls
- Age-matched controls
Main finding
As reported in the abstract
Average cerebral O2Hb response during exercise
SLE
1.20
± 0.89
Controls
2.69
± 2.46
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | SLE | Controls | P value |
|---|---|---|---|
| Peak cerebral O2Hb response during exerciseSignificantly lower in SLE | 2.89 ± 1.56 | 5.83 ± 4.59 | P = 0.004 |
- Serum brain derived neurotrophic factor (BDNF) levels · significantly lower in SLE
- P < 0.01
Original publication
Blunted cerebral oxygenation during exercise in systemic lupus erythematosus patients. Clin Exp Rheumatol. Published 17 November 2021. doi:10.
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